2022 Lexus RX 350 Review
Price Range: $32,395 - $48,476





+124
Good
7.7
out of 10
edmunds TESTED
With its combination of impressive attention to detail, interior appointments and practicality, the 2022 Lexus RX 350 has long been an attractive proposition in the luxury SUV scene. Though its bold styling might be a deterrent to some, the harsh and busy ride of the F Sport might be the RX 350's biggest misstep. The optional Mark Levinson audio system and well-calibrated driver aids help take the edge off any commute.
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2022 Lexus RX 350 Review
Pros
- Attractive cabin with top-quality materials and construction
- Super smooth ride
- Wide cargo bay makes it easy to load items
Cons
- Touchpad controller is distracting to use
- Real-world fuel economy lags behind estimates
What's new
- No significant changes for 2022
- Part of the fourth RX generation introduced for 2016
Overview

The Lexus RX has long been the quiet and comfortable choice in the luxury crossover SUV segment. The RX has for the most part kept up with the changing demands of the luxury SUV buyer — beyond the standard RX 350, there's a long-wheelbase version (RX 350L) as well as a hybrid variant (RX 450h), both of which are reviewed separately. This current-generation RX 350 is nearing the end of its run — it's been around since the 2016 model year — but it still offers a well-built, comfortable interior and remains a good value for your money.
For sale near Columbus, OH
873 listings
- $43,698great price$4,925 below market
- 24,589 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Meade Lexus of Lakeside (179 mi away)
- AWD/4WD
- Back-up camera
- Bluetooth
- Keyless Entry/Start
- Upgraded Headlights
Close
Located in Utica, MI
Heated Seats, Moonroof, Navigation, CD Player, iPod/MP3 Input, Satellite Radio, Power Liftgate, All Wheel Drive, INTUITIVE PARKING ASSIST W/PANORAMIC....
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA7NC363665
Stock: NC363665
Certified Pre-Owned: Yes
Listed since: 08-16-2025 - $37,112great price$3,225 below market
- 70,669 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Germain Lexus of Easton (3 mi away)
- AWD/4WD
- Back-up camera
- Bluetooth
- Keyless Entry/Start
- Upgraded Headlights
Close
Located in Columbus, OH
Grey AWD Automatic 3.5L V6 DOHC 24V Clean CARFAX. 2022 Lexus RX 350Certified. L/Certified Details: * Warranty Deductible: $0 * Roadside Assista...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA2NC318133
Stock: E10420A
Certified Pre-Owned: Yes
Listed since: 08-25-2025
All the same, it'll be worth your while to research a few other small or midsize luxury SUVs. The BMW X3 and Mercedes-Benz GLC blend modern technology, fuel efficiency and luxury in ways the Lexus can't quite match. And Acura's newly redesigned MDX offers comfort and a lot of standard features. For more details and specifics about the Lexus RX 350, check out our Expert Rating below.
Edmunds Expert Rating
edmunds TESTED
by the Edmunds Experts
Good
7.7
out of 10
We drove the 2022 Lexus RX 350 on our test track and on real roads. Our Edmunds team conducts rigorous independent vehicle testing, driving 500,000 miles a year.
Performance
7.5/10
How does the RX 350 drive? Outright performance isn't the name of the RX 350's game, even in F Sport trim. But when it comes to merging on a highway or overtaking slower traffic, the smooth and powerful V6 engine gets the job done. Accelerating to 60 mph takes 7.9 seconds, which isn't as quick as most competitors but is plenty adequate. More aggressive drivers will want to opt for the all-wheel drive for its superior traction.
The F Sport reduces body roll, but handling isn't really improved. The tires are the main letdown, but the Lexus can still confidently handle a twisty road. The brakes provide easy and smooth stopping power. The transmission is a little too eager to shift to a higher gear, but it does its work almost transparently.
The F Sport reduces body roll, but handling isn't really improved. The tires are the main letdown, but the Lexus can still confidently handle a twisty road. The brakes provide easy and smooth stopping power. The transmission is a little too eager to shift to a higher gear, but it does its work almost transparently.
Comfort
8/10
How comfortable is the RX 350? Comfort is paramount in a Lexus, and the RX 350 is generally excellent. The RX 350 can definitely take the edge off a long commute thanks to well-insulated windows, impressively comfortable seats covered in supple leather, and an effective and easy-to-use climate control system.
The only real negative, and it could be a deal-breaker, comes in the F Sport trim. In the attempt to achieve sportier handling, it throws any semblance of a relaxing ride right out the window. Moderately chewed-up roads will bounce and jitter occupants about in a very un-Lexus-like manner, and larger potholes can be jarring. We'd recommend steering clear of the F Sport.
The only real negative, and it could be a deal-breaker, comes in the F Sport trim. In the attempt to achieve sportier handling, it throws any semblance of a relaxing ride right out the window. Moderately chewed-up roads will bounce and jitter occupants about in a very un-Lexus-like manner, and larger potholes can be jarring. We'd recommend steering clear of the F Sport.
Interior
8/10
How’s the interior? Even though the base of the windshield looks to be pretty far away, the dashboard and all major controls fall easily to hand. The buttons are on the large side, clearly labeled and easy to press, and most everything you touch feels well engineered and well considered. All passengers will appreciate the large square door openings, and there's plenty of room for tall people in the front and the back. Even the panoramic sunroof doesn't take away much headroom.
Many systems can't be fully accessed without using the touchscreen or the accompanying touchpad interface, but we appreciate having a choice. Navigating the menus is relatively simple but can't be done as fluidly as you can in a BMW or a Mercedes.
Many systems can't be fully accessed without using the touchscreen or the accompanying touchpad interface, but we appreciate having a choice. Navigating the menus is relatively simple but can't be done as fluidly as you can in a BMW or a Mercedes.
Technology
7.5/10
How’s the tech? Lexus' Mark Levinson stereos are always a high point, and the big infotainment screen is crisp and appealing. Lexus' Enform app has a handful of useful features, but it only integrates a limited selection of third-party apps. Android Auto and Apple CarPlay smartphone integration operates fine for the most part, though some of our Android users experienced issues with some apps missing and sometimes had no functionality at all. Charging options are available for the first two rows, with a generous six USBs total.
Thanks to the abundance of well-labeled buttons, you can often sidestep the somewhat formal and command-heavy voice control system. Driver aids are well calibrated, and we didn't have any false alarms or overreactions, though we would like the adaptive cruise control to be a bit more responsive to traffic flow.
Thanks to the abundance of well-labeled buttons, you can often sidestep the somewhat formal and command-heavy voice control system. Driver aids are well calibrated, and we didn't have any false alarms or overreactions, though we would like the adaptive cruise control to be a bit more responsive to traffic flow.
Storage
8/10
How’s the storage? Thanks to its two-row configuration, there's always a good amount of storage — 18.4 cubic feet — in the trunk of the RX 350. That's not as big as some other midsize SUVs, but it's decent. And with 40/20/40-split folding rear seats, this luxury SUV has flexibility to carry an assortment of goods. It's even rated to tow 3,500 pounds, which, though far from class-leading, is enough for a small trailer with a motorcycle or two.
Passengers get a fair amount of well-thought-out storage for personal items, even including a cupholder whose depth can be adjusted for taller mugs. Child seats will also have ample room for attachment thanks to the large door openings and plenty of rear legroom.
Passengers get a fair amount of well-thought-out storage for personal items, even including a cupholder whose depth can be adjusted for taller mugs. Child seats will also have ample room for attachment thanks to the large door openings and plenty of rear legroom.
Fuel Economy
6.5/10
How’s the fuel economy? The front-wheel-drive RX350, with an EPA-estimated 23 mpg combined (20 city/27 highway), does little to distinguish itself in a competitive class. Our 115-mile highway-heavy evaluation loop returned just under 22 mpg, and to be honest we expected a bit more. On the plus side, the V6 engine doesn't require premium fuel unlike a lot of its turbocharged rivals.
Value
8/10
Is the RX 350 a good value? Fit and finish on the RX 350 leaves almost nothing to be desired, both inside and out. It's a rare moment when you come in contact with something other than leather or soft-touch plastics. Many manufacturers lack this level of attention to detail. But the price teetered on the edge of $60K for our optioned-up F Sport test vehicle.
Should you be able to go without some optional equipment, the standard RX 350 starts around $45K. We weren't overly impressed by the fuel economy we observed, but the warranties offered are good for the class and there's roadside assistance for four years with unlimited miles.
Should you be able to go without some optional equipment, the standard RX 350 starts around $45K. We weren't overly impressed by the fuel economy we observed, but the warranties offered are good for the class and there's roadside assistance for four years with unlimited miles.
Wildcard
7/10
Provided you don't spend the money on the misguided F Sport, the RX 350 is an impressively comfortable and serene place to spend your time. All passengers feel immediately at home in its spacious and well-equipped interior, and you'll start to wonder why even the gas pedal feels so good to the bottom of your shoe. The RX simply exudes quality.
But the F Sport gives that serenity a good and constant shaking and manages to upset a fairly luxurious experience. So too does the odd infotainment interface — it's been a source of frustration since its introduction. Thankfully you can get an RX without the stiff suspension and still revel in that excellent Mark Levinson audio system.
But the F Sport gives that serenity a good and constant shaking and manages to upset a fairly luxurious experience. So too does the odd infotainment interface — it's been a source of frustration since its introduction. Thankfully you can get an RX without the stiff suspension and still revel in that excellent Mark Levinson audio system.
2022 Lexus RX 350 trim level differences
The 2022 Lexus RX 350 comes in two trims: base and F Sport. Both are powered by a 3.5-liter V6 (295 horsepower, 267 lb-ft of torque) that's paired to an eight-speed automatic transmission. Front-wheel drive is standard, and all-wheel drive is optional. Feature highlights include:
Which RX 350 trim does Edmunds recommend?
We see no reason to stray from the base RX 350 since it offers plenty of available options. To that, we'd add the navigation system, the Mark Levinson audio system and the panoramic sunroof to round out the already luxurious interior. All-wheel drive is available, but we'd recommend steering clear of the F Sport since its firm ride runs counter to the RX's otherwise relaxed demeanor.
Compare 2022 Lexus RX 350 trim levels
Helpful trims summary and side-by-side comparison chart

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Cost to Drive
Monthly estimates based on costs in Ohio
$219/mo for RX 350 Base
RX 350 Base
vs
$179/mo
Avg. Midsize SUV
Reliability Ratings by RepairPal
4.5 out of 5 stars4.5/5Excellent
#3 out of 29 among Luxury Midsize SUVs
RepairPal Reliability Ratings are based on the actual cost, frequency, and severity of unscheduled repairs and maintenance on make/model data for select 2008-2022 vehicles. The reliability of a specific vehicle may vary depending on its maintenance and driving history, model year, trim, and features.
Cost
$408/yr
vs. $602/yr
for Average Luxury Midsize SUV
for Average Luxury Midsize SUV
Frequency
0.84x/yr
vs. 1.09x/yr
for Average Luxury Midsize SUV
for Average Luxury Midsize SUV
Severity
6.5%
vs. 9.4%
for Average Luxury Midsize SUV
for Average Luxury Midsize SUV
powered by RepairPal
Lexus RX 350 Owner Reviews
Most Helpful Owner Reviews
Trending topics
Exhaust drones/vibrates between 1400/1900 RPM
1 out of 5 starsAlanB, 09/30/2022
2022 Lexus RX 350 F SPORT 4dr SUV AWD (3.5L 6cyl 8A)
I have a new 2022 but the exhaust noise and corresponding vibration in the pedals and steering wheel is very annoying. Test drove another new 2022 today that did not have these issues. After two visits, a total of 11 days in the shop, and replacement of several parts the issue remains and Lexus has now washed their hands and told me that’s just too bad. It’s operating as intended in … their words, but obviously not, or they would not have worked on it two times and replaced parts. Very disappointed in Lexus quality and there their response to customer issues. If they don’t deal with this in a better fashion, they can put me down as a never again customer, and I warn everyone looking at ANY RX 350 to carefully check for this issue. All you have to do is leave the car in park, and very slowly rev the engine between idle and about 2000 RPM . If you hear any abnormal, droning , rumbling or vibrations run from the car, because Lexus will not fix it!
Exhaust Drone and Vibration Problems
1 out of 5 starsYalt, 03/21/2022
2022 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
Not sure about the statistic number, but a large amount(Maybe 50%) of RX350 has the Exhaust Drone and Vibration issue(Just google it). Lexus chooses to ignore it and note it as normal. Ironically they are pursuing 0 NVH(Noise, Vibration, Harshness) at the same time as Luxury Brand.
Be careful of this issue before you buy this car!!!
Love my 2022 RX350; learning features.
5 out of 5 starsRaymond, 08/31/2022
2022 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
I bought my RX350 Premium 2 weeks ago, only 42 miles driven so far. Drives smoothly and comfortably; no exhaust drone or vibration unlike the earlier review. I learned how to operate Android Auto so I can connect my smartphone by USB cable to use Google Maps. I did not get the Navigation System option but using Android Auto displays navigation on the standard 8-inch screen. I enjoy … the standard 9 speaker Lexus Multimedia System (has a CD player!) Don't believe all that hype about needing to order the Mark Levinson music system, unless you have to drive a concert hall all day long. Oh, yes. I have no problem using either the display screen or the touch pad on my 2022 RX350. I find the touch pad user friendly, and the standard 8-inch display screen is within easy reach for me to touch (I am 6-foot, 1 inch). The NuLuxe seats feel so plush and comfortable as I drive. I did not find LexusApp that useful. I really don't care to start my car using my smartphone. I prefer to hold my fob key and start my RX350 the old-fashioned way. Lexus Enform seems useful, but Amazon Alexa Compatible? I am driving a luxury SUV, not a living room! So far, I have not used the kick sensor for the power rear door. It's simple enough to touch the button on the rear tailgate. All my grocery bags are next to me in a shopping cart when I get to the car. I love having the moonroof and look forward to opening it in cooler weather. After reading all the marketing information about "paint protection film" or "ceramic coatings", I prefer to apply a paste or liquid wax which seems less intimidating to perform. I just don't draft behind tractor-trailers on the freeway and look far ahead for trouble on the road. I can always afford to get a quality paint job several years later if the front end and hood gets chipped up.
beauty and gremlins
1 out of 5 starshoward, 11/29/2022
2022 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
Our 2022 RX350 is very nicely finished, but they have never fixed the horrendous drone and vibration that many, but not all 2022's have which dealer personel say is normal and corporate said you it is normal. So learn to live with it. Poor answer when you spend 60k for a supposed "LUXURY TOYOTA PRODUCT". hk
2022 RX 350 Highlights
Base
Base MSRP Excludes Destination Fee | $45,920 |
---|---|
Engine Type | Gas |
Combined MPG | 23 MPG |
Cost to Drive | $219/month |
Seating | 5 seats |
Cargo Capacity All Seats In Place | 16.0 cu.ft. |
front wheel drive | |
Warranty | 4 years / 50,000 miles |
Safety
Our experts like the RX 350 models:
- Lexus Safety System+ 2.0
- Bundle includes adaptive cruise control, forward collision mitigation with automatic braking, and lane keeping assist.
- Lexus Enform Safety Connect
- This system can automatically alert emergency services in the event of a crash or distress. Also includes a stolen vehicle locator.
- Panoramic View Monitor
- The panoramic rearview camera maximizes the 12.3-inch widescreen display and gives a broad look at what's behind you before you back up.
NHTSA Overall Rating
4 out of 5 starsThe National Highway Transportation Safety Administration offers independent analysis.
- Frontal Barrier Crash RatingOverall4 / 5Driver3 / 5Passenger4 / 5
- Side Crash RatingOverall5 / 5
- Side Barrier RatingOverall5 / 5Driver5 / 5Passenger5 / 5
- Combined Side Barrier & Pole RatingsFront Seat5 / 5Back Seat5 / 5
- RolloverRollover4 / 5Dynamic Test ResultNo TipRisk Of Rollover17.9%
IIHS Rating
The Insurance Institute of Highway Safety uses extensive crash tests to determine car safety.
- Small Overlap Front Driver-Side TestGood
- Small Overlap Front Passenger-Side TestGood
- Moderate Overlap Front Test – OriginalGood
- Moderate Overlap Front Test – UpdatedNot Tested
- Side Impact Test – OriginalGood
- Side Impact Test – UpdatedNot Tested
- Roof Strength TestGood
- Rear Crash Protection / Head RestraintGood
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